Who Was Karen on General Hospital? Who Played the Role Karen Wexler on General Hospital?

Explore the rich history of General Hospital, the longest-running American soap opera, and its iconic character Karen Wexler. Learn about the talented actresses who played the role, from Cari Shayne to Jennifer Hammon and Marie Wilson, bringing depth and authenticity to this memorable character.

General Hospital

General Hospital is a well-known American TV show that began way back on April 1, 1963. It holds the record for being the longest-running American soap opera, second only to Guiding Light in U.S. history. The show initially took place in a fictional city at a hospital and later claimed its setting to be in Port Charles, New York. Families like Quartermaine and Spencer have been central to the stories since the late 1970s.

In the early 1980s, the show gained immense popularity, especially with the famous couple, Luke and Laura, whose 1981 wedding was watched by a massive 30 million people. General Hospital has welcomed renowned guests and garnered numerous awards, including 14 Daytime Emmy Awards for Outstanding Drama Series. Despite changes in TV, General Hospital adapted and began airing in high-definition in 2009. The show celebrated its 50th anniversary in 2013 and reached its 15,000th episode on June 22, 2022, solidifying its significance in TV history and culture.

Who Was Karen on General Hospital?

Karen on General Hospital was a beloved character who made her first appearance in March 1992. She was portrayed by the talented actress Cari Shayne until her departure in 1994. However, Karen’s story didn’t end there. She returned to the screens in June 1997 as part of the cast of the GH spinoff series Port Charles, with the role being recast with Jennifer Hammon. The character continued to evolve and captivate audiences until her final exit in June 1999, with Marie Wilson taking over the role. Tragically, Karen met her untimely demise in July 2003.

Karen Wexler’s journey on General Hospital was filled with intricate connections and emotional complexities. In her high school years, she was initially involved with Jason Quartermaine. However, her heart truly belonged to John “Jagger” Cates. Unfortunately, Brenda Barrett, another character, also had her sights set on Jagger and went to great lengths to keep Karen away from him. Despite the obstacles, Karen and Jagger eventually found their way to each other.

Karen’s character on General Hospital was defined by her resilience, vulnerability, and the challenges she faced. Her storylines captivated viewers, as they explored important issues such as abuse, trauma, and personal growth. Karen’s presence left a lasting impact on the show and the hearts of fans who followed her journey throughout the years.

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Who Played the Role Karen Wexler on General Hospital?

Marie Wilson played the role of Karen Wexler on General Hospital from 1999 to 2003. Karen Wexler was a fictional character who made a significant impact on the show during her time on screen. Her portrayal by Marie Wilson brought depth and authenticity to the character, captivating viewers with her performances. Karen Wexler was a medical doctor on the show, adding a layer of complexity and expertise to her persona.

Throughout her tenure, Karen’s character underwent various storylines and developments, capturing the hearts of fans who followed her journey. Marie Wilson’s portrayal of Karen Wexler solidified the character as a memorable figure in the world of General Hospital. With her talent and dedication, Wilson breathed life into Karen, making her relatable and endearing to the audience.

Her performances showcased Karen’s resilience, compassion, and determination as she navigated the challenges of being a doctor in a high-stakes environment. Fans were captivated by Karen’s storylines and emotionally invested in her relationships, both personal and professional.


General Hospital Cast



Cynthia Allison

Carolyn Craig

Jessie Brewer

Emily McLaughlin

Dr. Phil Brewer

Roy Thinnes

Angie Costello

Jana Taylor

Mike Costello

Ralph Manza

Fred Fleming

Simon Scott

Janet Fleming

Ruth Phillips

Dr. Steve Hardy

John Beradino

Roy Lansing

Robert Clarke

Priscilla Longworth

Allison Hayes

Dr. Ken Martin

Hunt Powers

Peggy Mercer

K. T. Stevens

Philip Mercer

Neil Hamilton

Mrs. Weeks

Lenore Kingston

Al Weeks

Tom Brown

Eddie Weeks

Craig Curtis

General Hospital Overview

Also known as



Soap opera

Created by

Frank & Doris Hursley

Country of origin

United States

Original language


No. of episodes


Production companies

Selmur Productions (1963–1968), ABC Signature (1985–present)




April 1, 1963 – present

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